5 ESSENTIAL ELEMENTS FOR BLISOVI FE 1/20

Sulfates are the foremost circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The main oxidative metabolite is 2-hydroxy ethinyl estradiol, formed by the CYP3A4 isoform of cytochrome P450. Section of the 1st-go metabolism of ethinyl estradiol is considered to take place in gastrointestinal mucosa. Ethinyl estradiol ma